Biochemical modification of titanium surfaces (BMTiS) entails immobilization of\nbiomolecules to implant surfaces in order to induce specific host responses. This crossover\nrandomized clinical trial assesses clinical success and marginal bone resorption of dental implants\nbearing a surface molecular layer of covalently-linked hyaluronan in comparison with control\nimplants up to 36 months after loading. Patients requiring bilateral implant rehabilitation received\nhyaluronan covered implants in one side of the mouth and traditional implants in the other side.\nTwo months after the first surgery, a second surgery was undergone to uncover the screw and to\nplace a healing abutment. After two weeks, the operator proceeded with prosthetic procedures.\nImplants were evaluated by periapical radiographs and the crestal bone level was recorded at mesial\nand distal sites-at baseline and up to 36 months. One hundred and six implants were positioned,\n52 HY-coated, and 48 controls were followed up. No differences were observed in terms of insertion\nand stability, wound healing, implant success, and crestal bone resorption at any time considered.\nAll interventions had an optimal healing, and no adverse events were recorded. This trial shows,\nfor the first time, a successful use in humans of biochemical-modified implants in routine clinical\npractice and in healthy patients and tissues with satisfactory outcomes.
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